| title | developer | year | platform | | pop. |
|---|
| Earth 2150: The Moon Project | Reality Pump Studios | 2000 | Windows | strategy Science Fiction | image | subject | label | |
| Earth 2160 | Reality Pump | 2005 | Windows | strategy Science Fiction | image | | label | |
| Earth-Port II | SoftSide | 1980 | TRS-80 | simulation flight | | | label | |
| EarthSiege | Dynamix | 1994 | MS-DOS | shooter simulation Science Fiction | image | | label | |
| EarthSiege 2: Skyforce | Dynamix | 1995 | Windows | simulation Science Fiction | image | | label | |
| Echo Night: Beyond | From Software | 2004 | PS2 | adventure Horror | image | | label | |
| Eden Star | Flix Interactive | 2015 | Windows | action/reflex simulation Science Fiction | image | | label | |
| egl | ? | 2006 | BSD | Horror | | | label | |
| Elegy for a Dead World | Dejobaan Games | 2014 | Windows | adventure | | subject | label | |
| Elegy for a Dead World | Dejobaan Games | 2014 | Linux | adventure | | subject | label | |
| Elegy for a Dead World | Dejobaan Games | 2014 | Mac OS X | adventure | | subject | label | |
| Emperor: Battle for Dune | Westwood Studios;Intelligent Games | 2001 | Windows | strategy Science Fiction | image | | label | |
| Endless Sky | author | 2015 | Linux | shooter simulation flight Science Fiction | | | label | |
| Endless Sky | author | 2015 | Windows | shooter simulation flight Science Fiction | | subject | label | |
| Escape Velocity | Ambrosia Software | 1996 | Mac OS Classic | flight role-play Science Fiction | image | subject | label | |
| Escape Velocity Nova | ATMOS;Ambrosia Software | 2002 | Mac OS X | flight role-play Science Fiction | image | subject | label | |
| Escape Velocity Nova | ATMOS Software;Ambrosia Software | 2003 | Windows | flight role-play Science Fiction | image | | label | |
| Escape Velocity Override | Ambrosia Software | 1998 | Mac OS Classic | flight role-play Science Fiction | image | subject | label | |
| EVE Online | CCP Games | 2007 | Linux | simulation role-play Science Fiction | | | label | |
| EVE Online | CCP Games | 2007 | Mac OS X | simulation role-play Science Fiction | | | label | |
| EVE Online | CCP Games | 2003 | Windows | simulation role-play Science Fiction | image | | label | |
| EVERSPACE | ROCKFISH Games | 2017 | Windows | shooter Science Fiction | image | | label | |
| EVERSPACE | ROCKFISH Games | 2017 | Xbox One | shooter Science Fiction | | | label | |
| Exodus from the Earth | Parallax Arts Studio | 2008 | Windows | shooter Science Fiction | image | subject | label | |
| Factorio | Wube Software | 2016 | Linux | action/reflex simulation strategy Science Fiction | | | label | |
| Factorio | Wube Software | 2016 | Windows | action/reflex simulation strategy Science Fiction | image | | label | |
| Factorio | Wube Software | 2016 | Mac OS X | action/reflex simulation strategy Science Fiction | | | label | |
| Famicom Macross | Namco | 198? | X68000 | | | | label | |
| FAR Colony | ? | ? | Windows | simulation manag./econ. | | | label | |
| Farscape | Red Lemon Studios | 2002 | Windows | action/reflex Science Fiction | image | | label | |
| Flash Gordon | TCFS | 1990 | C16/Plus4 | shooter | image | | label | |
| Flash Gordon | Universal | 1985 | Arcade | shooter Science Fiction | | | label | |
| Flash Gordon | Icon Design | 1987 | ZX Spectrum | action/reflex beat 'em up maze shooter Science Fiction | image | | label | |
| Flash Gordon | Icon Design | 1986 | C64 | action/reflex beat 'em up maze shooter Science Fiction | image | | label | |
| Flash Gordon | Icon Design | 1986 | Amstrad CPC | action/reflex beat 'em up maze shooter Science Fiction | image | | label | |
| Flash Gordon | Icon Design | 1986 | MSX | action/reflex beat 'em up maze shooter Science Fiction | image | | label | |
| Flash Gordon | 20th Century Fox | 1983 | Atari 2600 | shooter | image | | label | |
| Flashback | Delphine Software | 1992 | Amiga | action/reflex platformer adventure Science Fiction | image | | label | |
| Flashback | Delphine Software | 1993 | MS-DOS | action/reflex platformer adventure Science Fiction | image | | label | |
| Flashback | Delphine Software;U.S. Gold | 1992 | Archimedes | platformer adventure | image | | label | |
| Flashback | U.S. Gold;Delphine Software | 1994 | CD-I | action/reflex platformer adventure Science Fiction | image | | label | |
| Flashback | Delphine Software | 19?? | FM Towns | shooter adventure | | | label | |
| Flashback | VectorCell | 2013 | X360 | action/reflex platformer Science Fiction | | | label | |
| Flashback | VectorCell | 2013 | PS3 | action/reflex platformer Science Fiction | | | label | |
| Flashback | VectorCell | 2013 | Windows | action/reflex platformer Science Fiction | image | subject | label | |
| Flashback | Delphine Software | 1994 | Mac OS Classic | action/reflex platformer adventure Science Fiction | image | | label | |
| Flashback | Tiertex | 1995 | Jaguar | action/reflex platformer adventure Science Fiction | image | subject | label | |
| Flashback: The Quest for Identity | Delphine | 1993 | SNES | action/reflex platformer adventure Science Fiction | image | subject | label | |
| Flashback: The Quest for Identity | Delphine Software | 1993 | Mega-CD | action/reflex platformer adventure Science Fiction | image | subject | label | |
| Flashback: The Quest for Identity | Delphine | 1994 | 3DO | action/reflex platformer adventure Science Fiction | image | subject | label | |
| Flashback: The Quest for Identity | Delphine Software | 1993 | Mega Drive | action/reflex platformer adventure Science Fiction | image | subject | label | |
| Forsaken Sanctum | author | ? | Linux | role-play Fantasy | image | | label | |
| Frank Herbert's Dune | Cryo Interactive | 2001 | Windows | adventure Science Fiction | image | | label | |
| Frank Herbert's Dune | Cryo Interactive | 2001 | PS2 | action/reflex adventure Science Fiction | image | subject | label | |
| Free Stars: The Ur-Quan Masters | Pistol Shrimp | 2024 | Windows | shooter strategy Science Fiction | | subject | label | |
| Freelancer | Digital Anvil | 2003 | Windows | action/reflex shooter flight Science Fiction | image | subject | label | |
| Freelancer | author | 2016 | Linux | action/reflex shooter flight Science Fiction | | | label | |
| Freespace | Volition | 1998 | Windows | shooter simulation flight Science Fiction | image | | label | |
| Freespace: The Great War | Volition;author | 2002 | Linux | shooter simulation Science Fiction | | | label | |
| Frontier: Elite II | Gametek | 1993 | MS-DOS | simulation flight manag./econ. Science Fiction | image | | label | |
| Future Wars: Time Travellers | Delphine Software | 1989 | Amiga | adventure Science Fiction | image | | label | |
| Future Wars: Time Travellers | Delphine Software | 1990 | MS-DOS | adventure Science Fiction | image | | label | |
| Future Wars: Time Travellers | Delphine Software | 1989 | Atari ST | adventure Science Fiction | image | | label | |
| Future Wars: Toki no Boukensha | Voica and Image Products | 1991 | NEC PC9801 | adventure Science Fiction | image | | label | |
| Future Wars: Toki no Boukensha | Voice and Image Products | 1991 | X68000 | adventure Science Fiction | image | | label | |
