The protagonist, or at least a significant number of characters, really exist or have existed in life. May not apply to sport games as most of them feature real sportsmen.
The first video game about Real protagonist was released on December 10, 1986.
CharactersShaquille O'Neal, Michael Jackson, Albert Einstein, George Herbert Walker Bush, 50 Cent, Mata Hari, George Walker Bush, Jackie Chan, Douglas Adams
(view all the 9 "Real protagonist" characters)