| title | developer | year | game type | | pop. |
|---|
| NBA Jam | Midway;Iguana Entertainment | 1994 | Mega-CD | sport | image | | label | |
| NFL Football Trivia Challenge | CapDisc | 1994 | Mega-CD | sport trivia/quiz | image | subject | label | |
| NFL's Greatest: San Francisco VS Dallas 1978-1993 | Sega | 1993 | Mega-CD | sport | image | subject | label | |
| NHL '94 | High Score Productions | 1993 | Mega-CD | sport | image | | label | |
| Night Striker | Aisystem Tokyo | 1993 | Mega-CD | shooter | image | | | |
| Night Trap | Digital Pictures | 1992 | Mega-CD | action/reflex Horror | image | subject | label | |
| Nostalgia 1907 | Sega | 1993 | Mega-CD | adventure | image | | | |
| Novastorm | Psygnosis | 1994 | Mega-CD | shooter Science Fiction | image | | label | |
| Panic! | A-Wave | 1993 | Mega-CD | adventure puzzle Manga | image | | label | |
| Penn and Teller's Smoke and Mirrors | Absolute Entertainment | 1994 | Mega-CD | platformer shooter simulation racing/driving casino/cards puzzle role-play | | | label | |
| Pitfall: The Mayan Adventure | Activision | 1994 | Mega-CD | platformer | image | subject | label | |
| Popful Mail: Magical Fantasy Adventure | Falcom | 1994 | Mega-CD | beat 'em up platformer role-play Fantasy | image | | label | |
| Power Factory | Sony | 1992 | Mega-CD | rhythm | image | | label | |
| PowerMonger | Bullfrog | 1994 | Mega-CD | strategy | image | | label | |
| Prince of Persia | Brøderbund | 1992 | Mega-CD | platformer adventure Fantasy | image | | label | |
| Prize Fighter | Digital Pictures | 1994 | Mega-CD | fighting | image | | label | |
| Psychic Detective Volume 3: Aya | DAPS | 1993 | Mega-CD | adventure | image | | label | |
| Psychic Detective Volume 4: Orgel | DAPS | 1993 | Mega-CD | adventure | image | | label | |
| Puggsy | Traveller's Tales | 1993 | Mega-CD | platformer Cartoon | image | | label | |
| Quiz Scramble Special | Sega | 1992 | Mega-CD | trivia/quiz | image | | label | |
| Racing Aces | Hammond & Leyland | 1993 | Mega-CD | flight | image | | label | |
| Radical Rex | Beam Software | 1994 | Mega-CD | platformer | image | subject | label | |
| Ranma ½: White Orchid Serenade | Masaya | 1993 | Mega-CD | Manga | image | | label | |
| RDF: Global Conflict | Imagineering | 1995 | Mega-CD | shooter | image | subject | label | |
| Record of Lodoss War: The War of Heroes | JASPAC | 1994 | Mega-CD | role-play Manga | image | | label | |
| Revenge of the Ninja | Telenet Japan;Wolf Team | 1993 | Mega-CD | action/reflex adventure | image | | label | |
| Revengers of Vengeance | Micronet | 1994 | Mega-CD | fighting shooter role-play Fantasy | image | | label | |
| Rise of the Dragon | Dynamix;Game Arts;Bits Laboratory | 1992 | Mega-CD | adventure | image | | label | |
| Rise of the Phoenix | Koei | ? | Mega-CD | | | | label | |
| Road Avenger | Wolf Team;Data East | 1993 | Mega-CD | action/reflex Manga | image | | label | |
| Road Rash | Monkey Do Productions;New Level Software | 1994 | Mega-CD | racing/driving | image | | label | |
| Robo Aleste | Compile | 1992 | Mega-CD | shooter Manga | image | | label | |
| Romance of the Three Kingdoms 3: Dragon of Destiny | Koei | 1993 | Mega-CD | Historical | image | | label | |
| Samurai Shodown | Funcom | 1995 | Mega-CD | fighting | image | | label | |
| Sega Arcade Classics 5-in-1 | Sega | 1992 | Mega-CD | beat 'em up racing/driving puzzle | image | | label | |
| Sega Classic Arcade Collection | Sega | 1992 | Mega-CD | beat 'em up puzzle | image | | label | |
| Seireishin Seiki Fhey Area | Wolf Team | 1992 | Mega-CD | role-play Manga | image | | | |
| Sengoku Denshō | Sammy | 1993 | Mega-CD | beat 'em up Fantasy | image | | label | |
| Sewer Shark | Digital Pictures | 1992 | Mega-CD | maze shooter | image | | label | |
| Shadow of the Beast II | Reflections;Digital Developments | 1994 | Mega-CD | Fantasy | image | | label | |
| Shadowrun | Group SNE | 1996 | Mega-CD | adventure role-play Fantasy | image | | label | |
| Sherlock Holmes, Consulting Detective Vol. 1 | Icom Simulations | 1992 | Mega-CD | adventure | image | | label | |
| Sherlock Holmes, Consulting Detective Vol. 2 | Icom Simulations | 1993 | Mega-CD | adventure | image | | label | |
| Shin Megami Tensei | Sims | 1994 | Mega-CD | role-play | image | | label | |
| Shining Force CD | Sega | 1994 | Mega-CD | strategy role-play turn-based Fantasy | image | subject | label | |
| Silky Leap | Riot | 1992 | Mega-CD | adventure Manga | image | | label | |
| Silpheed | Game Arts | 1993 | Mega-CD | shooter Science Fiction | image | | label | |
| SimEarth: The Living Planet | Maxis;Game Arts | 1993 | Mega-CD | simulation manag./econ. | image | | label | |
| Slam City with Scottie Pippen | Digital Pictures | 1994 | Mega-CD | sport | image | | label | |
| Snatcher | Konami | 1994 | Mega-CD | adventure shooting gallery Manga | image | subject | label | |
| Sol Feace | Wolf Team | 1991 | Mega-CD | shooter Science Fiction | image | subject | label | |
| Sonic CD | Sonic Team | 1993 | Mega-CD | platformer Manga | image | subject | label | |
| Soul Star | Core Design | 1994 | Mega-CD | shooter | image | | label | |
| SoulFire | Sega | 1994 | Mega-CD | | | | label | |
| Space Ace | Epicenter Studios | 1993 | Mega-CD | action/reflex Science Fiction | image | subject | label | |
| Star Blade | Namco | 1994 | Mega-CD | shooter | image | | label | |
| Star Wars: Rebel Assault | LucasArts | 1994 | Mega-CD | shooter flight Science Fiction | image | | label | |
| Stellar-Fire | Infinite Laser Dogs | 1993 | Mega-CD | shooter strategy | image | | label | |
| Super League CD | Hudson | 1992 | Mega-CD | sport | image | | label | |
| Super League CD Deluxe | Hudson | 1993 | Mega-CD | sport | | | | |
| Supreme Warrior | Digital Pictures | 1994 | Mega-CD | fighting | image | subject | label | |
| Surgical Strike | The Code Monkeys;Stargate Films | 1993 | Mega-CD | action/reflex | image | | label | |
| Syndicate | Bullfrog | 1995 | Mega-CD | shooter strategy Science Fiction | image | | label | |
| Tenbu: Mega CD Special | Wolf Team | 1992 | Mega-CD | simulation strategy | image | | | |
| Tenkafubu | GameArts | 1991 | Mega-CD | strategy | image | | label | |
| The Adventures of Batman & Robin | Clockwork Tortoise | 1995 | Mega-CD | racing/driving Cartoon | image | | label | |
| The Adventures of Willy Beamish | Infinite Laser Dog | 1992 | Mega-CD | adventure Cartoon | image | | label | |
| The Amazing Spider-Man vs. the Kingpin | Sega | 1993 | Mega-CD | beat 'em up Cartoon | image | subject | label | |
| The Heroic Legend of Arislan | Sega | 1993 | Mega-CD | simulation Fantasy | image | | label | |
| The Lawnmower Man | Time Warner Interactive | 1994 | Mega-CD | action/reflex | image | | label | |
| The Masked Rider: Kamen Rider Zo | Sega | 1994 | Mega-CD | adventure | image | | label | |
| The Ninja Warriors | Taito | 1993 | Mega-CD | beat 'em up | image | | label | |
| The San Diego Zoo Presents...: The Animals! | Arnowitz Studios | 1994 | Mega-CD | edutainment | image | | label | |
| The Secret of Monkey Island | LucasArts | 1992 | Mega-CD | adventure Fantasy | image | | label | |
| The Smurfs | Virtual Studio | 1995 | Mega-CD | platformer Cartoon | image | | label | |
| The Software Toolworks' Star Wars Chess | The Software Toolworks | 1994 | Mega-CD | board game puzzle | image | | label | |
| The Space Adventure - COBRA - The Legendary Bandit | Hudson Soft | 1994 | Mega-CD | adventure Manga | image | subject | label | |
| The Terminator | Probe | 1993 | Mega-CD | Science Fiction | image | | label | |
| Theme Park | Bullfrog | 1995 | Mega-CD | simulation manag./econ. Humorous | image | | label | |
| Third World War | Micronet | 1993 | Mega-CD | strategy | image | | label | |
| Thunderstrike | Core Design | 1993 | Mega-CD | shooter | image | | label | |
| Time Gal | Wolf Team | 1992 | Mega-CD | action/reflex Manga | image | subject | label | |
| Tokyo Mahjong Gakuen | Asmik | 1996 | Mega-CD | | | | | |
| Tomcat Alley | The Code Monkeys | 1994 | Mega-CD | shooter flight | image | | label | |
| Trivial Pursuit: The Interactive Multimedia Game | Parker Brothers;Western Technologies | 1995 | Mega-CD | board game trivia/quiz | image | | label | |
| Ultraverse Prime | Sony Imagesoft | 1994 | Mega-CD | beat 'em up | image | | label | |
| Urusei Yatsura: My Dear Friends | Game Arts | 1994 | Mega-CD | Manga | image | | label | |
| Vay | Sims | 1994 | Mega-CD | role-play Fantasy | image | subject | label | |
| Virtual VCR: The Colors of Modern Rock | Sega | 1993 | Mega-CD | rhythm | | | | |
| Warau Salesman | Sega;Compile | 1993 | Mega-CD | adventure | image | | label | |
| Wheel of Fortune | Absolut | 1994 | Mega-CD | trivia/quiz | image | | label | |
| Who Shot Johnny Rock? | American Laser Games | 1993 | Mega-CD | shooting gallery | image | | label | |
| Wild Woody | Sega | 1995 | Mega-CD | platformer | image | | label | |
| Winds of Thunder | Red | 1993 | Mega-CD | shooter Manga | image | | label | |
| Wing Commander | Origin Systems;CRI;Game Arts | 1994 | Mega-CD | shooter flight Science Fiction | image | | label | |
| Winning Post | Koei | 1993 | Mega-CD | | image | | label | |
| Wire Head | The Code Monkeys | 1995 | Mega-CD | adventure | image | | label | |
| Wolfchild | Core Design | 1993 | Mega-CD | action/reflex platformer Science Fiction | image | | label | |
| Wonder Dog | Core Design | 1992 | Mega-CD | platformer | image | | label | |
| WonderMega Collection | JVC | 1992 | Mega-CD | | | | | |
| World Cup USA 94 | Tiertex | 1994 | Mega-CD | sport | image | | label | |
| WWF: Rage in the Cage | Sculptured Software | 1994 | Mega-CD | fighting | image | | label | |
| Yumemi Mystery Mansion | Vic Tokai | 1993 | Mega-CD | adventure Horror | image | | label | |
| Yumimi Mix | Game Arts | 1993 | Mega-CD | adventure Manga | image | | label | |
