The Simpsons is the longest-running animated television series and sitcom series in television history, debuted on 1989-11-17.
The first video game about The Simpsons was released in 1991.
Presumably The Simpsons universe does not contain humans, as there was an episode where Homer was turned into human (which included him having five fingers instead of four and non-yellow skin) to which he reacted with outright horror.
CharactersMarge Simpson, Bart Simpson, Krusty the Clown, Apu Nahasapeemapetilon, Jr., Homer Simpson, Lisa Simpson, Itchy, Maggie Simpson, Scratchy
(view all the 9 "The Simpsons" characters)