| title | developer | year | game type | | pop. |
|---|
| Ultima I: The First Age of Darknes | Pony Canyon | 1989 | MSX2 | role-play Fantasy | image | | label | |
| Ultima II: Revenge of the Enchantress | Newtopia Planning | 1989 | MSX2 | role-play Fantasy | image | | label | |
| Ultima III: Exodus | Newtopia Planning | 1988 | MSX2 | role-play Fantasy | image | | label | |
| Ultima III: Exodus | Pony Canyon | 1989 | MSX2 | role-play Fantasy | | | label | |
| Ultima IV: Quest of the Avatar | Newtopia Planning | 1987 | MSX2 | role-play Fantasy | image | | label | |
| Ultraman | Bandai | 1984 | MSX2 | action/reflex shooter Science Fiction | image | | label | |
| Urusei Yatsura - Koi No Survival Birthday | Micro Cabin | 1987 | MSX2 | adventure Manga | image | | label | |
| Usas | Konami | 1987 | MSX2 | platformer | image | | label | |
| Vampire | N.I | 1997 | MSX2 | action/reflex | image | | | |
| Vampire Killer | Konami | 1986 | MSX2 | action/reflex beat 'em up platformer Fantasy | image | | label | |
| Vectron | Parallax | 1989 | MSX2 | action/reflex | image | | | |
| Victorious Nine II | Taito | 1988 | MSX2 | sport | image | | | |
| Wallaby! | N.I | 1994 | MSX2 | action/reflex platformer puzzle | image | | | |
| Warau Salesman | Compile | 1991 | MSX2 | Manga | image | | | |
| Warning | Cosmos Computer | 1988 | MSX2 | adventure | image | | | |
| What's Michael? | Micro Cabin | 1989 | MSX2 | adventure Manga | image | | label | |
| Whipple | Takeru | 1992 | MSX2 | puzzle | image | | | |
| Wing Warriors | Kitmaker Entertainment | 2016 | MSX2 | shooter | image | | label | |
| Wingman Special | Enix | 1988 | MSX2 | adventure Manga | image | | label | |
| Wizardry II: The Knight of Diamonds | Foretune | 1989 | MSX2 | role-play Fantasy | image | | label | |
| Wizardry III: The Legacy of Llylgamyn | Foretune | 1990 | MSX2 | role-play Fantasy | image | | label | |
| Wizardry: Proving Grounds of the Mad Overlord | Foretune | 1987 | MSX2 | role-play Fantasy | image | | label | |
| Wolf AT | Tecnopolis Soft | 1990 | MSX2 | | image | | | |
| Wood | N.I | 1996 | MSX2 | action/reflex | image | | | |
| Woody Poco | dB-SOFT | 1987 | MSX2 | action/reflex adventure | image | | label | |
| World Golf | Enix | 1986 | MSX2 | sport | image | | label | |
| World Golf II | Enix | 1988 | MSX2 | sport | image | | label | |
| WXY | Clever Bits | 1988 | MSX2 | Erotic | | | | |
| X-Na | Fairytale | 1991 | MSX2 | adventure Manga | image | | | |
| Xak II: The Rising of the Redmoon | Micro Cabin | 1990 | MSX2 | action/reflex role-play Fantasy | image | | | |
| Xak III: The Tower of Gazzel | Micro Cabin | 1991 | MSX2 | action/reflex role-play Fantasy | image | | | |
| Xak: The Art of Visual Stage | Micro Cabin | 1989 | MSX2 | action/reflex role-play Fantasy | image | | | |
| Xevious: Fardraut Saga | Compile | 1988 | MSX2 | shooter Science Fiction | image | | label | |
| XZR II | Renovation Game | 1988 | MSX2 | action/reflex role-play Fantasy | image | | label | |
| XZR: Hakai no Guuzou | Renovation Game | 1988 | MSX2 | action/reflex role-play Fantasy | image | | label | |
| Yajiuma Pennant Race | Victor | 1989 | MSX2 | sport | image | | | |
| Yaksa | Wolf Team | 1988 | MSX2 | action/reflex role-play Fantasy | image | | label | |
| Yamamura Misa Suspense: Kyouto Ryuu no Tera Satsujin Jiken | Taito | 1988 | MSX2 | adventure Manga | image | | label | |
| Youma Kourin | Falcon | 1989 | MSX2 | beat 'em up Fantasy | image | | | |
| Young Artist | Alalamiah | 1988 | MSX2 | edutainment | image | | | |
| Ys II: Ancient Ys Vanished - The Final Chapter | Nihon Falcom | 1988 | MSX2 | action/reflex role-play Fantasy | image | | label | |
| Ys III: Wanderers from Ys | Nihon Falcom | 1989 | MSX2 | action/reflex role-play Fantasy | image | | label | |
| Yumeji | Fairytale | 1992 | MSX2 | Manga | image | | | |
| Yuurei-kun | System Sacom | 1988 | MSX2 | action/reflex platformer | image | | | |
| Yuureikun | System Sacom | 1988 | MSX2 | | image | | | |
| Zanac EX | Compile | 1986 | MSX2 | shooter Science Fiction | image | | label | |
| Zatsugaku Olympic | HARD | 1988 | MSX2 | puzzle Manga | image | | | |
| Zero: The 4th Unit Act.4 | Data West | 1990 | MSX2 | adventure Manga | | | | |
| Zevimodoki | GW’s Workshop | 2017 | MSX2 | shooter | image | | label | |
| Zoids: Chuuou Tairiku no Tatakai | Toshiba EMI | 1988 | MSX2 | role-play Science Fiction | image | | label | |
| Zombie Hunter | Hi-Score Software | 1988 | MSX2 | action/reflex role-play Fantasy | image | | | |
| Zoo | Radarsoft | 1987 | MSX2 | adventure | image | | label | |
| Zukkoke Yajikita Onmitsudoutyuu | HAL Laboratory | 1987 | MSX2 | action/reflex adventure | image | | label | |
