| title | developer | year | game type | | pop. |
|---|
| EA Playground | EA Canada | 2007 | Wii | action/reflex racing/driving | image | subject | label | |
| EA Sports Active | EA Canada | 2009 | Wii | sport | image | subject | label | |
| EA Sports Active 2 | EA Canada | 2010 | Wii | sport | image | | label | |
| EA Sports Active More Workouts | EA Canada | 2009 | Wii | sport | image | subject | label | |
| EA Sports Active NFL Training Camp | EA Canada | 2010 | Wii | sport | image | | label | |
| Earache Extreme Metal Racing | Data Design Interactive | 2008 | Wii | action/reflex racing/driving | | | | |
| Earth Seeker | Crafts & Meister | 2011 | Wii | action/reflex | | | | |
| Eat! Fat! Fight! | Tecmo | 2009 | Wii | action/reflex | image | subject | label | |
| Eclosion | Eipix | ? | Wii | shooter | | | | |
| Eco Shooter: Plant 530 | Intelligent Systems | 2009 | Wii | action/reflex | | subject | label | |
| Eduardo the Samurai Toaster | Semnat Studios | 2009 | Wii | beat 'em up | image | subject | label | |
| Eikan wa Kimini: Koukou Yakyuu Zengoku | Artdink | 2008 | Wii | sport | | | label | |
| El Chavo | Slang | 2012 | Wii | puzzle | | | | |
| Elebits | Konami | 2006 | Wii | action/reflex | image | subject | label | |
| Elebits 2 | Konami | ? | Wii | action/reflex | | | | |
| Elf Bowling | NStorm | ? | Wii | action/reflex sport | image | | label | |
| Emergency Heroes | Ubisoft Reflections | 2008 | Wii | adventure | image | | | |
| Emergency Mayhem | Supersonic Software | 2008 | Wii | action/reflex | image | | label | |
| Enclave: Shadows of Twilight | Village1 Entertainment | ? | Wii | action/reflex role-play | image | | | |
| Ender's Game: Battle Room | ? | ? | Wii | | | | | |
| Endless Ocean | Arika | 2007 | Wii | adventure | image | | label | |
| Endless Ocean: Blue World | Arika | 2010 | Wii | adventure | image | subject | label | |
| Enjoy Your Massage! | Microforum | 2010 | Wii | simulation | | subject | | |
| Ennichi no Tatsujin | Namco Bandai Games | 2006 | Wii | | image | | | |
| Epic Mickey | Junction Point Studios | 2010 | Wii | action/reflex platformer adventure | image | subject | label | |
| Epic Mickey 2: The Power of Two | Junction Point Studios | 2012 | Wii | action/reflex adventure | image | | label | |
| Equilibrio | DK Games | 2009 | Wii | puzzle | image | subject | label | |
| Escape from Bug Island | Spike | 2006 | Wii | action/reflex adventure Horror | image | subject | label | |
| Escape the Museum | Gogii Games | 2009 | Wii | puzzle | image | | | |
| escapeVektor: Chapter 1 | Nnooo | 2011 | Wii | action/reflex | image | subject | label | |
| Etch A Sketch | MumboJumbo | ? | Wii | puzzle | | | | |
| Eternity's Child | Oyaji Games | ? | Wii | platformer | | | | |
| Evasive Space | High Voltage Software | 2009 | Wii | shooter | image | | label | |
| Everyone Sing | O-Games | 2012 | Wii | rhythm | | | | |
| Everyone's Common Knowledge - Television | Nintendo | 2008 | Wii | trivia/quiz | | | | |
| Everyone's Theater | ? | 2009 | Wii | simulation | | | | |
| Excite Truck | Monster Games | 2006 | Wii | racing/driving | image | subject | label | |
| Excitebike: World Rally | Monster Games | 2009 | Wii | racing/driving | | | label | |
| Excitebots: Trick Racing | Monster Games | 2009 | Wii | racing/driving | image | | | |
| ExerBeat | Namco Bandai | 2011 | Wii | sport | image | subject | | |
| Explodemon! | Curve Studios | ? | Wii | platformer | | | | |
| Eye Shield 21 | Eighting | 2007 | Wii | sport | image | | | |
