| title | developer | year | game type | | pop. |
|---|
| Sadness | Nibris | 2009 | Wii | action/reflex adventure | | | label | |
| Safari Adventures in Africa | Conspiracy Entertainment;Neko Entertainment | 2009 | Wii | adventure | | | label | |
| Sakura Wars ~So Long, My Love~ | Idea Factory | 2010 | Wii | strategy adventure role-play turn-based Manga | image | subject | label | |
| Sam & Max Beyond Time and Space | Telltale Games | 2008 | Wii | adventure Cartoon | image | | label | |
| Samba de Amigo | Gearbox Software | 2008 | Wii | rhythm Humorous | image | | | |
| Samurai Shodown Anthology | SNK Playmore | 2009 | Wii | fighting | image | | label | |
| Samurai Warriors 3 | Omega Force | 2009 | Wii | action/reflex Historical | image | | label | |
| Samurai Warriors: Katana | Omega Force | 2007 | Wii | beat 'em up Historical | image | | label | |
| Sandy Beach | Frozen Codebase | 2009 | Wii | action/reflex | | | label | |
| Satisfashion | Destineer | 2010 | Wii | | | | | |
| Scarface: The World is Yours | Radical Entertainment | 2007 | Wii | action/reflex adventure | image | subject | label | |
| Science Papa | Activision | 2009 | Wii | | image | | | |
| Scooby-Doo! and the Spooky Swamp | Torus Games | 2010 | Wii | beat 'em up platformer Cartoon | image | | label | |
| Scooby-Doo! First Frights | Torus Games | 2009 | Wii | beat 'em up platformer Cartoon | | | label | |
| Score International Baja 1000: The Official Game | Left Field Productions | 2008 | Wii | racing/driving | | | label | |
| SD Gundam: Scad Hammers | Namco Bandai Games | 2007 | Wii | strategy Manga | | | label | |
| Sea Monsters: A Prehistoric Adventure | Atomic Planet Entertainment | 2007 | Wii | action/reflex adventure | image | | label | |
| Secret Files 2: Puritas Cordis | Animation Arts;Keen Games | 2009 | Wii | adventure | image | | label | |
| Secret Files: Tunguska | Fusionsphere Systems | 2009 | Wii | adventure | image | | label | |
| Sega Superstars Tennis | Sumo Digital | 2008 | Wii | sport | image | | label | |
| Sengoku Basara: Samurai Heroes | Capcom | 2010 | Wii | action/reflex beat 'em up | image | | label | |
| Sesame Street: Ready, Set, Grover! | Griptonite Games | 2011 | Wii | | image | | label | |
| Sexy Poker | Gameloft | 2009 | Wii | casino/cards Manga | image | subject | label | |
| Shakedown: Hawaii | Vblank Entertainment | 2020 | Wii | action/reflex shooter | | | | |
| Shaun White Snowboarding: World Stage | Ubisoft Montreal | 2009 | Wii | sport | image | subject | label | |
| Shimano Xtreme Fishing | Mastiff | 2009 | Wii | | image | | | |
| Shiren the Wanderer | Chunsoft | 2010 | Wii | role-play | image | subject | label | |
| Showtime Championship Boxing | Nikitova | 2007 | Wii | sport | image | | label | |
| Shrek Forever After | XPEC | 2010 | Wii | beat 'em up puzzle Fantasy | image | | label | |
| Shrek Smash n' Crash Racing | Torus Games | 2006 | Wii | racing/driving Cartoon | | | label | |
| Shrek the Third | Amaze Entertainment | 2007 | Wii | beat 'em up Cartoon | | | label | |
| Shrek the Third | Shaba Games | 2007 | Wii | action/reflex | image | | label | |
| Shrek's Carnival Craze | Ivolgamus | 2008 | Wii | action/reflex Cartoon | | | label | |
| Sidewinder | Codemasters | ? | Wii | | | | | |
| Silent Hill: Shattered Memories | Climax Studios | 2009 | Wii | action/reflex adventure Fantasy | image | subject | label | |
| Silver Star Chess | Agetec | 2009 | Wii | board game | | subject | label | |
| Silver Star Reversi | Agetec | 2009 | Wii | board game | | subject | label | |
| SimAnimals | Electronic Arts | 2009 | Wii | simulation edutainment Cartoon | image | | label | |
| Simple 2000 Series Wii Vol. 1: The Table Game | Yuki | 2008 | Wii | action/reflex board game | image | | label | |
| Simple 2000 Series Wii Vol. 2: The Party Game | Tamsoft | 2008 | Wii | action/reflex | image | | label | |
| Simple Wii Series Vol. 1: The Minna de Kart Race | TOSE | 2007 | Wii | racing/driving | image | | label | |
| Simple Wii Series Vol. 2: The Minna de Bass Tsuri Taikai | TOSE | 2007 | Wii | sport | image | | label | |
| Simple Wii Series Vol. 3: Ason de Wakaru - The Party Casino | D3 Publisher | 2007 | Wii | casino/cards | image | | label | |
| Simple Wii Series Vol. 4: The DokoDemo Asoberu - The Shooting Action | D3 Publisher | 2007 | Wii | shooter | image | | label | |
| Simple Wii Series Vol. 5: The Block Kuzushi | D3 Publisher | 2008 | Wii | action/reflex | image | | label | |
| Simple Wii Series Vol. 6: The Wai Wai Combat | D3 Publisher | 2008 | Wii | shooter | image | | label | |
| Sin & Punishment: Star Successor | Treasure | 2010 | Wii | shooter | image | subject | label | |
| Six Flags Fun Park | 7 Studios | 2009 | Wii | action/reflex adventure | image | | | |
| Sky Crawlers: Innocent Aces | Project Aces | 2008 | Wii | action/reflex flight | image | subject | label | |
| Skylanders: Giants | Toys For Bob | 2012 | Wii | fighting platformer | image | | label | |
| Skylanders: Spyro's Adventure | Toys For Bob | 2011 | Wii | beat 'em up | image | | label | |
| Skylanders: SuperChargers | Toys for Bob;Beenox | 2015 | Wii | | | | label | |
| Skylanders: Swap Force | Beenox | 2013 | Wii | action/reflex adventure | image | | label | |
| Skylanders: Trap Team | Toys for Bob | 2014 | Wii | | | | label | |
| Skyscraper | Atomic Planet | 2010 | Wii | shooter | image | | | |
| Smart Series Presents: JaJa's Adventure | UFO Interactive Games | 2010 | Wii | | | | | |
| Sniper Elite | Reef Entertainment | 2010 | Wii | | image | | | |
| SNK Arcade Classics Vol. 1 | SNK Playmore | 2008 | Wii | | image | | label | |
| Snowboard Riot | Hudson Soft | 2009 | Wii | sport | | subject | label | |
| So Blonde: Back to the Island | Wizarbox | 2010 | Wii | adventure Humorous | image | | label | |
| Sonic & Sega All-Stars Racing | Sumo Digital | 2010 | Wii | racing/driving | image | subject | label | |
| Sonic and the Black Knight | Sonic Team | 2009 | Wii | adventure | image | | label | |
| Sonic and the Secret Rings | Sonic Team | 2007 | Wii | action/reflex platformer adventure Manga | image | subject | label | |
| Sonic Colors | Sonic Team | 2010 | Wii | platformer | image | subject | label | |
| Sonic Riders: Zero Gravity | Sonic Team | 2008 | Wii | racing/driving | image | | label | |
| Sonic Unleashed | Sonic Team;Dimps | 2008 | Wii | action/reflex beat 'em up Fantasy | image | | label | |
| Soul Eater: Monotone Princess | Square Enix;Bones | 2008 | Wii | action/reflex adventure Fantasy | | | label | |
| SoulCalibur Legends | Namco Bandai Games | 2007 | Wii | action/reflex adventure | image | | label | |
| Space Chimps | Brash Entertainment | 2008 | Wii | platformer adventure | | | | |
| Space Invaders - Get Even | Taito | 2008 | Wii | shooter | image | subject | label | |
| Space Station Tycoon | Wahoo Studios | 2007 | Wii | simulation | image | | | |
| Spaceball Revolution | Virtual Toys | 2009 | Wii | action/reflex puzzle | image | subject | | |
| Spaghetti Western Shooter | BigBen Interactive | 2011 | Wii | | | | | |
| Spectrobes: Origins | Genki | 2009 | Wii | action/reflex adventure | image | subject | | |
| Speed Racer | Sidhe Interactive | 2008 | Wii | racing/driving | image | | label | |
| Spider-Man 3 | Vicarious Visions | 2007 | Wii | action/reflex | image | | label | |
| Spider-Man: Edge of Time | Beenox | 2011 | Wii | | image | | label | |
| Spider-Man: Friend or Foe | Next Level Games | 2007 | Wii | action/reflex beat 'em up | image | | label | |
| Spider-Man: Shattered Dimensions | Beenox | 2010 | Wii | action/reflex adventure | image | subject | label | |
| Spider-Man: Web of Shadows | Activision | 2008 | Wii | action/reflex | image | | label | |
| Splinter Cell: Double Agent | Ubisoft Montreal | 2006 | Wii | action/reflex Science Fiction | image | | label | |
| SPOGS Racing | Pronto Games | 2008 | Wii | racing/driving | image | subject | label | |
| SpongeBob SquarePants: Creature from the Krusty Krab | Blitz Games | 2006 | Wii | action/reflex platformer racing/driving | image | | label | |
| SpongeBob's Atlantis Squarepantis | Blitz Games | 2007 | Wii | action/reflex | image | | label | |
| SpongeBob's Boating Bash | Impulse Games | 2010 | Wii | racing/driving | image | subject | label | |
| Spore | Maxis | 2008 | Wii | simulation manag./econ. Science Fiction | | | label | |
| Spore Hero | Maxis | 2009 | Wii | action/reflex simulation adventure | image | subject | label | |
| Springdale: Riding Adventures | Hidden Entertainment | 2010 | Wii | | image | | label | |
| Sprint Cars | Brain in a Jar | 2011 | Wii | racing/driving | | | label | |
| Spyborgs | Bionic Games | 2009 | Wii | action/reflex adventure | image | subject | label | |
| SSX Blur | EA Montreal | 2007 | Wii | sport | image | subject | label | |
| Star Soldier R | Hudson Soft | 2008 | Wii | shooter Science Fiction | image | subject | label | |
| Star Trek: Conquest | 4J studios | 2007 | Wii | action/reflex strategy Science Fiction | image | subject | label | |
| Star Wars The Clone Wars: Republic Heroes | Krome Studios | 2009 | Wii | action/reflex Cartoon | image | subject | label | |
| Star Wars: The Clone Wars - Lightsaber Duels | Krome Studios | 2008 | Wii | fighting Science Fiction | image | | label | |
| Star Wars: The Force Unleashed | LucasArts;Krome Studios | 2008 | Wii | action/reflex | image | subject | label | |
| Star Wars: The Force Unleashed II | LucasArts;Red Fly Studio | 2010 | Wii | action/reflex | image | | label | |
| Stonekeep: Bones of the Ancients | Alpine Studios | 2012 | Wii | action/reflex Fantasy | image | | label | |
| Story Hour Adventures | Other Ocean Interactive | 2009 | Wii | | | | | |
| Story Hour: Fairy Tales | Zoo | 2008 | Wii | | | | | |
| Strong Bad Episode 2: Strong Badia the Free | Telltale Games | 2008 | Wii | adventure Humorous | | subject | label | |
| Strong Bad Episode 3: Baddest of the Bands | Telltale Games | 2008 | Wii | | | subject | label | |
| Strong Bad Episode 4: Dangeresque 3 | Telltale Games | 2008 | Wii | action/reflex | | subject | label | |
| Strong Bad's Cool Game for Attractive People - Episode 1: Homestar Ruiner | Telltale Games | 2008 | Wii | adventure Humorous | image | subject | label | |
| Strong Bad's Cool Game for Attractive People Episode 5: 8-Bit is Enough | Telltale Games | 2008 | Wii | adventure | | | label | |
| Sudoku Challenge! | Digital Leisure | 2008 | Wii | puzzle | image | subject | label | |
| Sukeban Shachō Rena Wii | Jorudan | 2009 | Wii | action/reflex | image | | label | |
| Summer Athletics | 49 Games | 2008 | Wii | sport | image | | label | |
| Super Fruit Fall | System 3 | 2006 | Wii | | image | | | |
| Super Mario All-Stars - 25th Anniversary Edition | Nintendo | 2010 | Wii | platformer | image | | label | |
| Super Mario Galaxy | Nintendo | 2007 | Wii | platformer adventure | image | subject | label | |
| Super Mario Galaxy 2 | Nintendo EAD | 2010 | Wii | action/reflex platformer | image | subject | label | |
| Super Meat Boy | Team Meat | 2010 | Wii | action/reflex platformer Cartoon | | | label | |
| Super Monkey Ball Step & Roll | Sega | 2010 | Wii | action/reflex | image | subject | label | |
| Super Monkey Ball: Banana Blitz | Sega Studios | 2006 | Wii | action/reflex racing/driving | image | subject | label | |
| Super Paper Mario | Intelligent Systems | 2007 | Wii | platformer Cartoon | image | subject | label | |
| Super PickUps | Milestone srl | 2008 | Wii | | | | | |
| Super Robot Wars NEO | Banpresto | 2009 | Wii | strategy role-play Science Fiction | image | | label | |
| Super Smash Bros. Brawl | Sora;Game Arts | 2008 | Wii | action/reflex beat 'em up fighting platformer adventure | image | subject | label | |
| Super Swing Golf | Ntreev Soft | 2006 | Wii | sport | image | subject | label | |
| Surf's Up | Ubisoft Montreal | 2007 | Wii | racing/driving sport | image | | label | |
| Suzumiya Haruhi no Gekidō | Kadokawa Shoten | 2009 | Wii | adventure rhythm Manga | image | subject | label | |
| Suzumiya Haruhi no Heiretsu | Sega | 2009 | Wii | adventure Manga | image | | label | |
| Suzumiya Haruhi no Yuuutsu | Kadokawa Shoten | 2008 | Wii | rhythm | | | | |
| Swords & Soldiers | Ronimo Games | 2009 | Wii | strategy Cartoon | image | subject | label | |
