| title | developer | year | game type | | pop. |
|---|
| Yakyukyo - Baseball Crazy | Hudson Soft | 1984 | MSX | sport | image | | label | |
| Yami no Ryu Ou Hades no Monshou | Casio | 1986 | MSX | action/reflex | image | | | |
| Yellow Submarine | Takeru | 1987 | MSX | shooter | image | | label | |
| Yesod | Unicornio Soft | 1987 | MSX | platformer | image | | label | |
| Yie Ar Kung-Fu | Konami | 1985 | MSX | fighting | image | | label | |
| Yie Ar Kung-Fu II: The Emperor Yie-Gah | Konami | 1985 | MSX | fighting | image | | label | |
| Yokai Tanken Chima Chima | Bothtec;Alexbros | 1985 | MSX | action/reflex | image | | | |
| Yokai Yashiki | Casio | 1986 | MSX | platformer | image | | label | |
| Young Artist | Alalamiah | 1988 | MSX | edutainment | image | | | |
| Young Sherlock | Pack-In-Video | 1987 | MSX | adventure | image | | label | |
| Yuki | Omega System | 1986 | MSX | | | | | |
| Yume Tairiku Adventure | Konami | 1986 | MSX | action/reflex Cartoon | image | | label | |
| Zaider: Battle of Peguss | Cosmos Computer | 1987 | MSX | shooter Science Fiction | image | | label | |
| Zakil Wood | Mr. Micro | 1985 | MSX | adventure Fantasy | image | | label | |
| Zampabolas | System 4 | 1990 | MSX | action/reflex board game | | | label | |
| Zanac A.I. | Compile | 1986 | MSX | shooter Science Fiction | image | | label | |
| Zarth | Enix | 1985 | MSX | adventure Manga | image | | | |
| Zasu | Enix | 1985 | MSX | Manga | image | | | |
| Zaxxon | Sega | 1985 | MSX | shooter Science Fiction | image | | label | |
| Zenji | Pony Canyon | 1984 | MSX | action/reflex puzzle | image | | label | |
| Zero and the Castle of Infinite Sadness | Alfonso D.C. | 2014 | MSX | maze | image | | | |
| Zexas | dB-SOFT | 1984 | MSX | shooter Science Fiction | image | | label | |
| Zexas Limited | dB-SOFT | 1985 | MSX | shooter Science Fiction | image | | label | |
| Zipi y Zape | Dro Soft | 1989 | MSX | adventure | image | | label | |
| Zipper | Kuma Computers | 1985 | MSX | action/reflex | image | | | |
| Zoids: The Battle Begins | Martech;Software Communications | 1986 | MSX | shooter strategy Science Fiction | image | | label | |
| Zombie incident | Nenefranz | 2012 | MSX | platformer | image | | label | |
| Zombie Near | author | 2010 | MSX | action/reflex | image | | | |
| Zona 0 | Topo Soft | 1991 | MSX | action/reflex Science Fiction | image | | label | |
| Zond: The Final Combat | Genesis Soft | 1988 | MSX | shooter Science Fiction | image | | label | |
| Zone TNT | Gamecast Entertainment | 2011 | MSX | maze shooter | image | | label | |
| Zoot | Bug-Byte | 1986 | MSX | action/reflex | image | | label | |
| Zork I: The Great Underground Empire | Infocom | 198? | MSX | adventure Fantasy | image | subject | label | |
